In vitro studies on the relative sensitivity to ivermectin of Necator americanus and Ancylostoma ceylanicum
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In vitro studies on the relative sensitivity to ivermectin of Necator americanus and Ancylostoma ceylanicum.
Experiments were carried out to compare the sensitivity of Ancylostoma ceylanicum and Necator americanus to ivermectin (IVM) and pyrantel in vitro. Loss of motility and inhibition of ingestion by IVM were compared and A. ceylanicum was found to be approximately 40-50 times more sensitive to IVM than N. americanus. Both species showed a similar sensitivity to pyrantel. Uptake of [3H]IVM across t...
متن کاملIn Vitvo Studies on the Relative Sensitivity to Ivermectin of Necator americanus and Ancylostoma ceylanicum
Richards J. C., Rebnke J. M. & Duce I. R. 1995. In uifro studies oo tbe relative sensitivity to ivermectin of Necator americanus and AncyIostoma ceyhnicum. International Journal for Parasitology 25: 1185-1191. Experiments were carried out to compare tbe sensitivity of Ancylostoma ceyhnicum and Necator umericunus to ivermectin (IVM) and pyrantel in vitro. Loss of motility and inhibition of inges...
متن کاملSensitivity to ivermectin and pyrantel of Ancylostoma ceylanicum and Necator americanus.
Experiments were carried out in the hamster to compare the relative susceptibility of Necator americanus and Ancylostoma ceylanicum to treatment with ivermectin. A. ceylanicum was found to be 300 times more sensitive to the anthelmintic with a 50% effective dose (ED50) of the order of 10-15 micrograms kg-1 body weight whilst that for N. americanus approximated to 3-5 mg kg-1. Furthermore, where...
متن کاملMolecular Detection of Ancylostoma duodenale, Ancylostoma ceylanicum, and Necator americanus in Humans in Northeastern and Southern Thailand
The 2 principal species of hookworms infecting humans are Necator americanus and Ancylostoma duodenale. Case studies on zoonotic hookworm infections with Ancylostoma ceylanicum and/or Ancylostoma caninum are known mainly from Asian countries. Of these 2 zoonotic species, only A. ceylanicum can develop to adulthood in humans. In the present study, we report a molecular-based survey of human hook...
متن کاملNecator americanus and Ancylostoma ceylanicum: development of protocols for dual infection in hamsters.
Two-day-old baby hamsters were infected initially with the infective larvae of hamster-adapted human hookworm, Necator americanus (NaL3). After a specified period they were again infected orally with infective larvae of Ancylostoma ceylanicum (AcL3). Three weeks after the second infection they were killed and the establishment of N. americanus and A. ceylanicum was assessed. The effect of diffe...
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ژورنال
عنوان ژورنال: International Journal for Parasitology
سال: 1995
ISSN: 0020-7519
DOI: 10.1016/0020-7519(95)00036-2